HEPATIC TOXICITY RESULTING FROM CANCER-TREATMENT

被引:534
作者
LAWRENCE, TS
ROBERTSON, JM
ANSCHER, MS
JIRTLE, RL
ENSMINGER, WD
FAJARDO, LF
机构
[1] UNIV MICHIGAN, SCH MED, DEPT RADIAT ONCOL, ANN ARBOR, MI USA
[2] UNIV MICHIGAN, SCH MED, DEPT INTERNAL MED, ANN ARBOR, MI USA
[3] UNIV MICHIGAN, SCH MED, DEPT PHARMACOL, ANN ARBOR, MI USA
[4] DUKE UNIV, SCH MED, DEPT RADIAT ONCOL, DURHAM, NC USA
[5] STANFORD UNIV, SCH MED, DEPT PATHOL, PALO ALTO, CA 94304 USA
[6] DEPT VET AFFAIRS MED CTR, PALO ALTO, CA USA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1995年 / 31卷 / 05期
关键词
LATE EFFECTS; RADIATION-INDUCED LIVER DISEASE; HEPATIC IRRADIATION; VENOOCCLUSIVE DISEASE;
D O I
10.1016/0360-3016(94)00418-K
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation-induced liver disease (RILD), often called radiation hepatitis, is a syndrome characterized by the development of anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. There has been a renewed interest in hepatic irradiation because of two significant advances in cancer treatment: three dimensional radiation therapy treatment planning and bane marrow transplantation using total body irradiation. RILD resulting from liver radiation can usually be distinguished clinically from that resulting from the preparative regime associated with bone marrow transplantation. However, both syndromes demonstrate the same pathological lesion: veno-occlusive disease. Recent evidence suggests that elevated transforming growth factor beta levels may play a role in the development of veno-occlusive disease. Three dimensional treatment planning offers the potential to determine the radiation dose and volume dependence of RILD, permitting the safe delivery of high doses of radiation to parts of the liver. The chief therapy for RILD is diuretics, although some advocate steroids for severe cases. The characteristics of RILD permit the development of a grading system modeled after the NCI Acute Common Toxicity Criteria, which incorporates standard criteria of hepatic dysfunction.
引用
收藏
页码:1237 / 1248
页数:12
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