CARRAGEENAN EDEMA AND SPINAL FOS-LI NEURONS ARE REDUCED BY PIROXICAM IN THE RAT

被引：8

作者：

BURITOVA, J ^{[1
]}

HONORE, P ^{[1
]}

CHAPMAN, V ^{[1
]}

BESSON, JM ^{[1
]}

机构：

[1] EPHE,F-75014 PARIS,FRANCE

来源：

NEUROREPORT | 1995年 / 6卷 / 10期

关键词：

INFLAMMATORY PAIN; CARRAGEENAN; PIROXICAM; C-FOS; SPINAL CORD; RAT;

D O I：

10.1097/00001756-199507100-00006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

INTRAPLANTAR carrageenan induced a peripheral oedema and c-Fos like immunoreactivity (Fos-LI) in L4-L5 segments in the dorsal horn (DH) of the rat spinal cord. The total number of carrageenan evoked Fos-LI neurones was 153+/-10 per section, with a predominant localization in the superficial and deep laminae of the DH (46+/-4% and 32+/-2%, respectively). Pre-administered piroxicam (1, 2.5 and 5 mg kg(-1), p.o.) dose-dependently reduced the number of Fos-LI neurones in both the superficial and deep laminae of DH, with effects being significantly strongest on the deep laminae Fos-LI neurones. The effects of piroxicam on the number of spinal Fos-LI neurones and on ankle oedema were positively correlated.

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页码：1385 / 1388

页数：4

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