Pictet-Spengler reaction of biogenic amines with (2R)-N-glyoxyloylbornane-10,2-sultam. Enantioselective synthesis of (S)-(+)-N-methylcalycotomine

被引：28

作者：

Czarnocki, Z

Mieczkowski, JB

Kiegiel, J

Arazny, Z

机构：

[1] Department of Chemistry, University of Warsaw, 02-093 Warsaw

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 12期

关键词：

D O I：

10.1016/0957-4166(95)00380-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(2R)-N-Glyoxyloylbornane-10,2-sultam reacted with dopamine hydrochloride, forming the Pictet-Spengler condensation product, which was further converted into (S)-(+)-N)-methylcalycotomine of high enantiomeric purity. The same kind of reaction with tryptamine hydrochloride gave the condensation product with 100% d.e.

引用

页码：2899 / 2902

页数：4

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