ADENOSINE DEAMINASE POLYMORPHISM IN MAN

被引：498

作者：

SPENCER, N

HOPKINSON, DA

HARRIS, H

机构：

[1] Department of Biochemistry, King's College London

[2] Medical Research Council, Human Biochemical Genetics Research Unit, Galton Laboratory, University College London

来源：

ANNALS OF HUMAN GENETICS | 1968年 / 32卷

关键词：

D O I：

10.1111/j.1469-1809.1968.tb00044.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A new and specific method for the study of adenosine deaminase isozymes is described. Examination of red‐cell lysates has revealed three genetically determined electrophoretically different ADA phenotypes: ADA 1, ADA 2–1 and ADA 2. Family studies indicate that these phenotypes are determined by two alleles, ADA1 and ADA2 at an autosomal locus. Preliminary population data suggest that ADA2 has a frequency of about 0.06 in European, 0.04 in Negroes and 0.11 in Asiatic Indians. The behaviour of the ADA isozyme pattern on storage or after treatment with thiol reagents suggests the occurrence of reactive sulphydryl groups in the enzyme molecules. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：9 / +

页数：1

共 5 条

[1] Adenosine deaminase [J].