EXPRESSION OF GENES-CODING FOR PS2, C-ERBB2, ESTROGEN-RECEPTOR AND THE H23 BREAST TUMOR-ASSOCIATED ANTIGEN - A COMPARATIVE-ANALYSIS IN BREAST-CANCER

被引：44

作者：

ZARETSKY, JZ ^{[1
]}

WEISS, M ^{[1
]}

TSARFATY, I ^{[1
]}

HAREUVENI, M ^{[1
]}

WRESCHNER, DH ^{[1
]}

KEYDAR, I ^{[1
]}

机构：

[1] SHEBA MED CTR,DEPT INTERNAL MED,TEL HASHOMER,ISRAEL

来源：

FEBS LETTERS | 1990年 / 265卷 / 1-2期

关键词：

Breast cancer; Breast tumor antigen H23; Breast tumor antigen pS2; Estrogen receptor; Gene expression; Oncogene erbB2;

D O I：

10.1016/0014-5793(90)80880-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the gene coding for a new breast tumor-associated antigen, H23, was compared to expression of genes coding for pS2, c-erbB2 and estrogen receptor (ER). Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA dot blot and Northern hybridizations showed that expression of the H23 antigen coding gene is a discriminatory marker in human breast cancer. It is expressed in 92% of breast tumors whereas 69%, 62% and 56% of breast tumors demonstrate significant mRNA levels of c-erbB2, ER and pS2, respectively. Non-malignant or normal breast tissue expresses much lower levels of the H23 antigen mRNA. From the comparative analysis presented here it is concluded that the gene coding for H23 antigen furnishes a most useful marker for human breast cancer. © 1990.

引用

页码：46 / 50

页数：5

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