ENZYMATIC FORMATION OF AN 8,9-DIOL FROM 8-METHYLBENZ[A]ANTHRACENE

被引：33

作者：

YANG, SK ^{[1
]}

CHOU, MW ^{[1
]}

WEEMS, HB ^{[1
]}

FU, PP ^{[1
]}

机构：

[1] NATL CTR TOXICOL RES,JEFFERSON,AR 72079

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91154-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An optically active 8,9-diol has been identified as a rat liver microsomal metabolite of the carcinogenic 8-methylbenz[a]anthracene. This is the first example indicating that the presence of a methyl group in a polycyclic aromatic hydrocarbon does not sterically block the enzymatic formation of a diol at the methyl-substituted double bond. © 1979.

引用

页码：1136 / 1141

页数：6

共 13 条

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