TRANSDERMAL UPTAKE OF A PEPTIDE-HORMONE - INHIBITION BY CALCITONIN EARDROPS OF INDUCED OSTEOLYSIS IN GUINEA-PIG OSSICLES

被引：3

作者：

RUDMAN, CG

PARSONS, JA

机构：

[1] Laboratory for Endocrine Physiology and Pharmacology, National Institute for Medical Research, London, NW7 1AA, Mill Hill

来源：

EXPERIENTIA | 1979年 / 35卷 / 04期

关键词：

D O I：

10.1007/BF01922745

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In view of a recent proposal that calcitonin injections may arrest the bony pathology of otosclerosis, we have tested the possibility of obtaining locally effective concentrations by giving salmon calcitonin in eardrops. Osteolysis of guinea-pig ossicles induced by injecting parathyroid hormone shortly before explantation was markedly inhibited by 3 days prior instillation of the calcitonin in an aqueous vehicle or in dimethyl sulphoxide, but not by a solution in propylene carbonate. © 1979 Birkhäuser Verlag.

引用

页码：521 / 522

页数：2

共 9 条

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