ABSORPTION OF CYTOKINES VIA OROPHARYNGEAL-ASSOCIATED LYMPHOID-TISSUES - DOES AN UNORTHODOX ROUTE IMPROVE THE THERAPEUTIC INDEX OF INTERFERON

被引:50
作者
BOCCI, V
机构
[1] Institute of General Physiology and Nutritional Sciences, Faculty of Pharmacy, University of Siena
[2] Institute of General Physiology, University of Siena, Siena, 853100, via Laterina
关键词
D O I
10.2165/00003088-199121060-00002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent data have suggested the possibility of stimulating the immune system by administering physiological doses of IFN via the oropharyngeal tissues. If these results can be confirmed, there will be millions of patients with acute and chronic viral diseases, residual minimal disease and immune depression able to take advantage of an extremely simple, inexpensive and well tolerated therapeutic modality. This approach only appears to be new and probably operates in the development of the immature immune system during the breast-feeding period. However, despite this and despite a rational background reviewed here, since this proposal does not fit conventional schemes, it has (correctly) been met with remarkable scepticism and prejudice. The aim of this article has been to point out that there are anatomical, immunological and pharmacological data suggesting that the approach is meaningful. Appropriate double-blind clinical trials are needed to prove its validity. © 1991, Adis International Limited. All rights reserved.
引用
收藏
页码:411 / 417
页数:7
相关论文
共 44 条
  • [1] INTERFERON-GAMMA FOR THE TREATMENT OF METASTATIC RENAL-CANCER - DOSE-DEPENDENT STIMULATION AND DOWN-REGULATION OF BETA-2 MICROGLOBULIN AND NEOPTERIN RESPONSES
    AULITZKY, W
    GASTL, G
    AULITZKY, WE
    NACHBAUR, K
    LANSKE, B
    KEMMLER, G
    FLENER, R
    FRICK, J
    HUBER, C
    [J]. IMMUNOBIOLOGY, 1987, 176 (1-2) : 85 - 95
  • [2] BLALOCK JE, 1982, TEX REP BIOL MED, V41, P344
  • [3] BOCCI V, 1988, IMMUNOLOGY, V64, P1
  • [4] EVALUATION OF ROUTES OF ADMINISTRATION OF INTERFERON IN CANCER - A REVIEW AND A PROPOSAL
    BOCCI, V
    [J]. CANCER DRUG DELIVERY, 1984, 1 (04): : 337 - 351
  • [5] BOCCI V, 1988, J BIOL REG HOMEOS AG, V2, P107
  • [6] BOCCI V, 1985, J BIOL RESP MODIF, V4, P340
  • [7] BOCCI V, 1990, J BIOL REG HOMEOS AG, V4, P81
  • [8] BOCCI V, 1990, EOS J IMMUNOLOGY IMM, V10, P7982
  • [9] BOCCI V, 1985, INTERFERON SYSTEM, V24, P129
  • [10] BOCCI V, 1990, ADV DRUG DELIVERY RE, V4, P149