SULTRIECIN, A NEW ANTIFUNGAL AND ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-ROSEISCLEROTICUS - PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引：37

作者：

OHKUMA, H

NARUSE, N

NISHIYAMA, Y

TSUNO, T

HOSHINO, Y

SAWADA, Y

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 08期

关键词：

D O I：

10.7164/antibiotics.45.1239

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces roseiscleroticus L827-7 (ATCC 53903) produced a novel antifungal and antitumor antibiotic, sultriecin. It exhibited in vitro antifungal activity and potent in vivo antitumor activity against P388 and L1210 leukemias, and B16 melanoma. Sultriecin is composed of several unique structural units; a conjugated triene, an alpha,beta-unsaturated delta-lactone, and a sulfate functionality.

引用

页码：1239 / 1249

页数：11

共 18 条

[1] STUDIES ON NEW PHOSPHATE ESTER ANTIFUNGAL ANTIBIOTICS PHOSLACTOMYCINS .2. STRUCTURE ELUCIDATION OF PHOSLACTOMYCIN-A TO PHOSLACTOMYCIN-F [J].