HUMAN PERIPHERAL-NERVE MACROPHAGES IN NORMAL AND PATHOLOGICAL CONDITIONS

被引：33

作者：

BONETTI, B ^{[1
]}

MONACO, S ^{[1
]}

GIANNINI, C ^{[1
]}

FERRARI, S ^{[1
]}

ZANUSSO, GL ^{[1
]}

RIZZUTO, N ^{[1
]}

机构：

[1] UNIV VERONA,INST NEUROL,I-37134 VERONA,ITALY

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1993年 / 118卷 / 02期

关键词：

IMMUNOCYTOCHEMISTRY; IMMUNE ELECTRON MICROSCOPY; PERIPHERAL NERVOUS SYSTEM; HLA-DR-POSITIVE MACROPHAGES; HLA-DR EXPRESSION; PERIPHERAL NEUROPATHY; COMPLEMENT RECEPTORS; (HUMAN);

D O I：

10.1016/0022-510X(93)90105-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated, by immunocytochemistry and immune electron microscopy, the immunophenotype, morphology and functional properties of human peripheral nervous system (PNS) macrophages (MPHI) under normal and pathological conditions. Endoneurial MPHI disclosed an elongated, ramified morphology, with the main processes oriented along the major axis of nerve fibers; they shared several lineage-related and functional markers with monocyte/macrophages and central nervous system (CNS) microglia, including CD4, CR3, CR4 and FcRIII. In addition, basal expression of HLA-DR antigens was exclusively confined to MP in normal PNS. In the course of unrelated pathological conditions, resident MPHI underwent activation with transformation to hypertrophic cells or foamy phagocytes and up-regulation of the markers expressed in normal conditions; new expression of a macrophagic antigen was detected on activated MP. In different neuropathies, HLA-DR expression was also detected on non-myelin forming Schwann cells with ultrastructural features indicative of denervation. The present results demonstrate that the human PNS is provided with an intrinsic population of immunocompetent and potentially phagocytic MPHI, which represent the peripheral counterpart of CNS microglia.

引用

页码：158 / 168

页数：11

共 39 条

[1] DEMONSTRATION AT THE SINGLE-CELL LEVEL OF THE EXISTENCE OF DISTINCT CLUSTERS OF EPITOPES IN 2 PREDEFINED HUMAN IA MOLECULAR SUBSETS [J].