A SOLID-PHASE CBZ CHLORIDE EQUIVALENT - A NEW MATRIX SPECIFIC LINKER

Treatment of TentaGel S resin (1) with phosgene provides matrix linked chloroformate (2), which is converted to the corresponding carbamoylated derivatives 3a and 3b. Alternatively, Wang resin provides the imidazolide (7a), which is readily transformed to amides and esters by treatment with nitrogen and carbon nucleophiles, respectively.