TOTAL SYNTHESIS OF ANALOGS OF TOPOSTIN-B, A DNA TOPOISOMERASE-I INHIBITOR .2. SYNTHESIS OF TOPOSTIN-B-1 ANALOGS

被引:4
作者
NOGUCHI, H [1 ]
AOYAMA, T [1 ]
SHIOIRI, T [1 ]
机构
[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,MIZUHO KU,NAGOYA,AICHI 467,JAPAN
关键词
D O I
10.1016/0040-4020(95)00617-H
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The analogs 1a and 1b of topostin B-1, an inhibitor of mammalian DNA topoisomerase I, has been synthesized in a convenient manner.
引用
收藏
页码:10545 / 10560
页数:16
相关论文
共 10 条
[1]  
ANDOH T, COMMUNICATION
[2]   NEW METHODS AND REAGENTS IN ORGANIC-SYNTHESIS .67. A GENERAL-SYNTHESIS OF DERIVATIVES OF OPTICALLY PURE 2-(1-AMINOALKYL)THIAZOLE-4-CARBOXYLIC ACIDS [J].
HAMADA, Y ;
SHIBATA, M ;
SUGIURA, T ;
KATO, S ;
SHIOIRI, T .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (07) :1252-1255
[3]  
HASHIMOTO N, 1981, CHEM PHARM BULL, V29, P1475
[4]   TOPOSTIN, A NOVEL INHIBITOR OF MAMMALIAN DNA TOPOISOMERASE-I FROM FLEXIBACTER-TOPOSTINUS SP-NOV .2. PURIFICATION AND SOME PROPERTIES OF TOPOSTIN [J].
IKEGAMI, Y ;
TAKEUCHI, N ;
HANADA, M ;
HASEGAWA, Y ;
ISHII, K ;
ANDOH, T ;
SATO, T ;
SUZUKI, K ;
YAMAGUCHI, H ;
MIYAZAKI, S ;
NAGAI, K ;
WATANABE, S ;
SAITO, T .
JOURNAL OF ANTIBIOTICS, 1990, 43 (02) :158-162
[5]   A NEW EFFICIENT SYNTHESIS OF (S)-DOLAPHENINE ((S)-2-PHENYL-1-(2-THIAZOLYL)ETHYLAMINE), THE C-TERMINAL UNIT OF DOLASTATIN-10 [J].
IRAKO, N ;
HAMADA, Y ;
SHIOIRI, T .
TETRAHEDRON, 1992, 48 (35) :7251-7264
[6]   A SYNTHESIS OF THE TETRAENE FRAGMENT OF CALYCULINS AS ITS ANTIPODAL FORM [J].
MATSUBARA, J ;
NAKAO, K ;
HAMADA, Y ;
SHIOIRI, T .
TETRAHEDRON LETTERS, 1992, 33 (29) :4187-4190
[7]  
MIWA K, 1994, SYNLETT, P461
[8]  
SAIOMON CJ, 1991, TETRAHEDRON LETT, V32, P4239
[9]  
Shioiri T., 1993, ADV USE SYNTHONS ORG, V1, P51
[10]   TOPOSTIN, A NOVEL INHIBITOR OF MAMMALIAN DNA TOPOISOMERASE-I FROM FLEXIBACTER-TOPOSTINUS SP-NOV .1. TAXONOMY, AND FERMENTATION OF PRODUCING STRAIN [J].
SUZUKI, K ;
YAMAGUCHI, H ;
MIYAZAKI, S ;
NAGAI, K ;
WATANABE, S ;
SAITO, T ;
ISHII, K ;
HANADA, M ;
SEKINE, T ;
IKEGAMI, Y ;
ANDOH, T .
JOURNAL OF ANTIBIOTICS, 1990, 43 (02) :154-157