NONSPECIFIC INTERSTITIAL PNEUMONITIS WITHOUT EVIDENCE OF PNEUMOCYSTIS-CARINII IN ASYMPTOMATIC PATIENTS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV)

被引:85
作者
OGNIBENE, FP [1 ]
MASUR, H [1 ]
ROGERS, P [1 ]
TRAVIS, WD [1 ]
SUFFREDINI, AF [1 ]
FEUERSTEIN, I [1 ]
GILL, VJ [1 ]
BAIRD, BF [1 ]
CARRASQUILLO, JA [1 ]
PARRILLO, JE [1 ]
LANE, HC [1 ]
SHELHAMER, JH [1 ]
机构
[1] NIAID, BETHESDA, MD 20205 USA
关键词
D O I
10.7326/0003-4819-109-11-874
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To assess how often Pneumocystis carinii organisms, P. carinii pneumonia, or other pulmonary pathologic processes were present in persons infected with human immunodeficiency virus (HIV) without pulmonary symptoms or previous history of P. carinii, and with a normal chest roentgenogram. Serial, prospective assessment of eligible HIV-seropositive patients over 21 months. Twenty-four HIV-seropositive patients with either a nonpulmonary manifestation of the acquired immunodeficiency syndrome (AIDS) (n = 12) or an absolute CD4 lymphocyte count of 0.200 .times. 109 cells/L or less (n = 12), no pulmonary symptoms, a normal chest roentgenogram, no history of P. carinii pneumonia, and no history of treatment with antipneumocystis prophylaxis. Pulmonary assessment with arterial blood gases, pulmonary function tests, gallium-67 citrate scans, and bronchoscopy with bronchalveolar lavage and transbronchial biopsies. Conclusions: HIV-infected patients without pulmonary symptoms did not have detectable Pneumocystis organisms in bronchoalveolar lavage fluid or transbronchial biopsy specimens; but 11 of 23 had evidence of chronic, nonspecific interstitial pneumonitis. Pneumocystis organisms in a pulmonary specimen from a symptomatic patient probably indicate the cause of the pulmonary dysfunction even if only a few are detected.
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收藏
页码:874 / 879
页数:6
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