ARE THE KNOWN DELTA-2-CEPHEMS INACTIVE AS ANTIBIOTICS BECAUSE OF AN UNFAVORABLE STERIC ORIENTATION OF THEIR 4-ALPHA-CARBOXYLIC GROUP - SYNTHESIS AND BIOLOGY OF 2 DELTA-2-CEPHEM-4-BETA-CARBOXYLIC ACIDS

被引：21

作者：

COHEN, NC

ERNEST, I

FRITZ, H

FUHRER, H

RIHS, G

SCARTAZZINI, R

WIRZ, P

机构：

[1] CIBA GEIGY AG, DIV PHARMACEUT, CH-4002 BASEL, SWITZERLAND

[2] CIBA GEIGY AG, CENT FUNCT RES, CH-4002 BASEL, SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1987年 / 70卷 / 07期

关键词：

D O I：

10.1002/hlca.19870700732

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：1967 / 1979

页数：13

共 11 条

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JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (02) :259-264

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[5]

MAIN P, 1978, SYSTEM COMPUTER PROG

[6] NEW BETA LACTAM ANTIBIOTICS - DERIVATIVES OF 3-HYDROXY-7-AMINO-CEPH-3-EME-4-CARBONIC ACID .10. MODIFICATIONS OF ANTIBIOTICS [J].

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BICKEL, H .

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[7]

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[8]

SEDELMEIER G, 1984, Patent No. 4436903

[9] MECHANISM OF ACTION OF PENICILLINS - A PROPOSAL BASED ON THEIR STRUCTURAL SIMILARITY TO ACYL-D-ALANYL-D-ALANINE [J].

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STROMINGER, JL .

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[10]

WIRZ P, UNPUB

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