SOLVENCY AND HYDROGEN BONDING INTERACTIONS IN NONAQUEOUS SYSTEMS

被引：43

作者：

HIGUCHI, T

RICHARDS, JH

DAVIS, SS

KAMADA, A

HOU, JP

NAKANO, M

NAKANO, NI

PITMAN, IH

机构：

[1] School of Pharmacy, The University of Wisconsin, Madison, Wisconsin

[2] Department of Analytical Pharmaceutical Chemistry and Pharmaceutics, The University of Kansas, Lawrence, Kansas

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 06期

关键词：

Complex formation—hydrogen bonding interaction; Linear free energy relationship—hydrogen bonding; Liquid‐liquid partition method—association constants; Optical rotatory dispersion method—association constants; Solubility method—association constants; Solvency‐hydrogen bonding interactions—non‐aqueous systems; Solvent effects—stability constants; complexes; UV spectrophotometry method—association constants;

D O I：

10.1002/jps.2600580603

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A study of the importance of hydrogen‐bonding interactions in the formation of complexes is useful in providing knowledge of the physical and chemical properties of drug molecules and hopefully it will eventually lead to rational formulation of drugs into suitable dosage forms. The present report deals with a study of some of the methods available for the experimental measurement of these interactions and the means of determining the association (equilibrium) constants from the experimental results. An attempt is made to develop suitable methods for the quantitative analysis of hydrogen‐bonding data so that useful estimates of association constants can be made a priori. The effect of the non‐aqueous solvent on the value of the association constant is also discussed and a method is given whereby an estimate of solvent interaction can be calculated. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：661 / &

共 98 条

[1] INTERMOLECULAR HYDROGEN BOND ASSOCIATION BETWEEN PHENOL AND ORGANOPHOSPHORUS COMPOUNDS [J].