DISTRIBUTION OF SPONTANEOUS CHROMOSOME-ABERRATIONS IN BHK21-C13 FIBROBLASTS

被引：5

作者：

NELSON, WJ ^{[1
]}

机构：

[1] INST CANC RES,DEPT PHYS,SUTTON,SURREY,ENGLAND

来源：

MUTATION RESEARCH | 1979年 / 59卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0027-5107(79)90157-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previous investigations of spontaneous aberrations in mammalian cells have been carried out on large heterogeneous samples of individuals, each of whom had had a different exposure to exogenous clastogens. In the present analysis using Syrian Hamster cells, a large number of metaphases were analysed from one sample of control cells. In this way all cells were exposed to the same doses of any unknown clastogens. The overall distribution of spontaneous breaks was found to be nonrandom. Breaks involved in different types of aberration had a nonrandom distribution, which was specific for each type. (e.g. terminal deletion and rearrangement). © 1979.

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页码：195 / 201

页数：7

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