CONCENTRATIONS OF TEMAFLOXACIN IN SERUM AND BRONCHIAL-MUCOSA

被引：16

作者：

BALDWIN, DR ^{[1
]}

WILKINSON, L ^{[1
]}

ANDREWS, JM ^{[1
]}

ASHBY, JP ^{[1
]}

WISE, R ^{[1
]}

HONEYBOURNE, D ^{[1
]}

机构：

[1] DUDLEY RD GEN HOSP,DEPT MED MICROBIOL,BIRMINGHAM B18 7QH,W MIDLANDS,ENGLAND

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1990年 / 9卷 / 06期

关键词：

D O I：

10.1007/BF01979477

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The bronchial mucosal concentrations of temafloxacin hydrochloride were determined in specimens obtained at fibreoptic bronchoscopy and compared with simultaneous serum concentrations. The 18 patients studied were given an oral dose of 400 mg b.i.d. for three days to achieve steady state levels. The mean serum concentration was 6.9 mg/l (SD 2.5 mg/l) and the mean bronchial mucosal concentration 12.2 mg/kg (SD 4 mg/kg). The mucosal levels exceeded those required to inhibit most of the common respiratory pathogens, including Streptococcus pneumoniae and Pseudomonas aeruginosa. These data support the use of temafloxacin for therapy of bronchial infections. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

引用

页码：432 / 434

页数：3

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