THE EFFECTS OF LOW-DENSITY LIPOPROTEINS ON UPTAKE OF PHOTOFRIN-II

被引：30

作者：

KORBELIK, M

HUNG, J

LAM, S

PALCIC, B

机构：

[1] British Columbia Cancer Research Centre, Vancouver, British Columbia, V5Z 1L3

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 51卷 / 02期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01702.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The cellular uptake of Photofrin II (PII) was studied using fluorescence imaging and chemical extraction. The influence of serum and low density lipoproteins (LDL) was examined under a variety of experimental conditions employing cultured human cells of different origins as well as a subcutaneously SMT‐F tumor implanted in mice. Results showed that serum inhibited PII uptake. In general, LDL also inhibits PII uptake with the exception of an initial increase in the first10–30 min when the cellular concentration of PII was measured by fluorescence imaging instead of chemical extraction. Our results suggest a possible de‐aggregation process occurring upon internalization or binding of PII to LDL. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：191 / 196

页数：6

共 30 条

[1]

BOHMER RM, 1985, CANCER RES, V45, P5328

[2] RECEPTOR-DEPENDENT HYDROLYSIS OF CHOLESTERYL ESTERS CONTAINED IN PLASMA LOW-DENSITY LIPOPROTEIN [J].