EFFECT OF CLOFIBRATE ON THE COA THIOESTER PROFILE IN RAT-LIVER

Acute and chronic treatment with clofibrate increased the total CoA content of rat liver and altered the profile of the various CoA thioesters. A 2- to 3-fold increase in the contents of long chain acyl CoA, acetyl CoA and free CoA resulted, contrasting with significant decreases found in succinyl CoA, malonyl CoA and acetoacetyl CoA contents. The known increase in fatty acid binding protein and/or the increased extramitochondrial .beta.-oxidation of fat by an increased peroxisomal population may direct the compartmentation and metabolic fate of fatty acids and their CoA derivatives following clofibrate treatment.