SUBSTITUTED CYCLIC IMIDES AS POTENTIAL ANTIGOUT AGENTS

被引：66

作者：

HALL, IH

SCOVILLE, JP

REYNOLDS, DJ

SIMLOT, R

DUNCAN, P

机构：

[1] Division of Medicinal Chemistry, Natural Products School of Pharmacy, Chapel Hill, NC 27599

来源：

LIFE SCIENCES | 1990年 / 46卷 / 26期

关键词：

D O I：

10.1016/0024-3205(90)90507-N

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N-substituted cyclic imides of phthalimide, 2,3-dihydrohalazine-1,4 4-dione, and diphenimide were shown to reduce the serum uric acid levels in normal and hyperuric mice at 20 mg/kg/day I.P. for 14 days. The agents were potent inhibitors of commercial xanthine dehydrogenase and xanthine oxidase enzyme activities with IC50 values from 10-7 to 10-8 M concentrations of drug. © 1990.

引用

页码：1923 / 1927

页数：5

共 9 条

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