MONOCLONAL-ANTIBODY IMMUNOTHERAPY IN NUDE-MICE PERSISTENTLY INFECTED WITH CRYPTOSPORIDIUM-PARVUM

被引：48

作者：

BJORNEBY, JM ^{[1
]}

HUNSAKER, BD ^{[1
]}

RIGGS, MW ^{[1
]}

PERRYMAN, LE ^{[1
]}

机构：

[1] WASHINGTON STATE UNIV,DEPT VET MICROBIOL & PATHOL,PULLMAN,WA 99164

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 03期

关键词：

D O I：

10.1128/IAI.59.3.1172-1176.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three groups of congenitally athymic nude mice were persistently infected following oral administration of 2 x 10(7) Cryptosporidium parvum oocysts. Two groups were treated once daily for 10 days with either neutralizing monoclonal antibody (MAb) 17.14 or an isotype control MAb. The third group received no treatment. Intestinal-infection scores were significantly decreased in nude mice treated with MAb 17.41 compared with isotype control MAb-treated and nontreated control groups (P < 0.005). Biliary and pancreatic cryptosporidial-infection scores were similar for the MAb 17.41-treated and isotype control MAb-treated groups (P > 0.05).

引用

页码：1172 / 1176

页数：5

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