1,N-2-ETHENOGUANOSINE - 3 METHODS OF SYNTHESIS

被引：18

作者：

BORYSKI, J

机构：

[1] Institute of Bioorganic Chemistry, Polish Academy of Scieeces, Noskowskiego 12/14 Poznań

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1990年 / 9卷 / 06期

关键词：

D O I：

10.1080/15257779008043146

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three novel approaches to synthesis of 1,N2 -ethenoguanosine rrom guanosine: i) reaction with aq. chloroacet-aldehyde at pH 9–10 ii) application of anhydrous chloro- and bromoacetaldehydes iii) 1-alkylation with bromoacetaldehyde diethyl acetal, subsequent hydrolysis to aldehyde on the nucleoside level and cyclization - afforded the title compound in satisfactory yields. © 1990, Taylor & Francis Group, LLC. All rights reserved.

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页码：803 / 813

页数：11

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