A DIRECT REPEAT IN THE CELLULAR RETINOL-BINDING PROTEIN TYPE-II GENE CONFERS DIFFERENTIAL REGULATION BY RXR AND RAR

被引：610

作者：

MANGELSDORF, DJ ^{[1
]}

UMESONO, K ^{[1
]}

KLIEWER, SA ^{[1
]}

BORGMEYER, U ^{[1
]}

ONG, ES ^{[1
]}

EVANS, RM ^{[1
]}

机构：

[1] SALK INST BIOL STUDIES,LA JOLLA,CA 92186

来源：

CELL | 1991年 / 66卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0092-8674(81)90018-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). We provide evidence that expression of the gene for cellular retinol-binding protein type II (CRBPII), a key protein in the intestinal absorption of vitamin A, is dramatically up-regulated by retinoic acid in the presence of RXR but not RAR. This regulation is conferred through a specific cis element in the CRBPII promoter that contains five nearly perfect tandem repeats of the sequence AGGTCA spaced by a single nucleotide. The discovery of this new RX response element provides a means for distinguishing between the two retinoid receptor systems and suggests that an RXR-mediated pathway exists for modulating vitamin A metabolism.

引用

页码：555 / 561

页数：7

共 29 条

[1] CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT [J].