BIOLOGICALLY-ACTIVE METABOLITES FROM XENORHABDUS SPP .2. BENZOPYRAN-1-ONE DERIVATIVES WITH GASTROPROTECTIVE ACTIVITY

被引：168

作者：

MCINERNEY, BV

TAYLOR, WC

LACEY, MJ

AKHURST, RJ

GREGSON, RP

机构：

[1] UNIV SYDNEY,DEPT HUMAN ANAT,SYDNEY,NSW 2006,AUSTRALIA

[2] CSIRO,DIV ENTOMOL,CANBERRA,ACT 2601,AUSTRALIA

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 03期

关键词：

D O I：

10.1021/np50075a006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel antibiotic compounds, named xenocoumacins 1 {2} and 2 {3}, with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive H-1-nmr, C-13-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.

引用

页码：785 / 795

页数：11

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