IMPROVEMENT IN COGNITIVE-FUNCTIONING OF ALCOHOLICS FOLLOWING ORTHOTOPIC LIVER-TRANSPLANTATION

被引:41
作者
ARRIA, AM
TARTER, RE
STARZL, TE
VANTHIEL, DH
机构
[1] UNIV PITTSBURGH,WESTERN PSYCHIAT INST & CLIN,SCH MED,DEPT SURG,PITTSBURGH,PA 15213
[2] UNIV PITTSBURGH,SCH MED,PITTSBURGH,PA 15213
关键词
NEUROPSYCHOLOGICAL DEFICITS; HEPATIC ENCEPHALOPATHY; ALCOHOLIC CIRRHOSIS; LIVER TRANSPLANTATION;
D O I
10.1111/j.1530-0277.1991.tb05195.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Cognitive functioning in alcoholic cirrhotics before and 1 year following orthotopic liver transplantation was compared with age- and sex-matched normal subjects. The alcoholic group improved significantly following transplantation on tests measuring psychomotor, visuopractic and abstracting abilities whereas the performance of normal controls remained virtually unchanged. In contrast, memory capacity in alcoholics with cirrhosis did not statistically improve following successful transplantation. Further investigation, using more sophisticated measures of memory function, are required to determine whether memory deficits are either associated with alcohol neurotoxicity or an irreversible component of hepatic encephalopathy. These findings suggest that a reversible hepatic encephalopathy underlies many of the neuropsychologic deficits observed in cirrhotic alcoholics and can be ameliorated following successful liver transplantation.
引用
收藏
页码:956 / 962
页数:7
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