LEPTOSINS, ANTITUMOR METABOLITES OF A FUNGUS ISOLATED FROM A MARINE ALGA

被引：137

作者：

TAKAHASHI, C

NUMATA, A

ITO, Y

MATSUMURA, E

ARAKI, H

IWAKI, H

KUSHIDA, K

机构：

[1] OSAKA UNIV PHARMACEUT SCI,MATSUBARA,OSAKA 580,JAPAN

[2] FUSO PHARMACEUT IND LTD,JOTO KU,OSAKA 532,JAPAN

[3] VARIAN INSTRUMENTS LTD,SHINJUKU KU,TOKYO 169,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 13期

关键词：

D O I：

10.1039/p19940001859

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Leptosins A B, C, D, E and F, chaetocin derivatives, have been isolated from the mycelium of a strain of Leptosphaeria so. attached to the marine alga Sargassum tortile. Their stereostructures, with a different configuration from that of related compounds, have been elucidated by spectroscopic analyses using various 1D and 2D NMR techniques and some chemical transformations. All the compounds showed potent cytotoxicity against cultured P388 cells, and leptosins A and C exhibited significant antitumour activity against Sarcoma 180 ascites.

引用

页码：1859 / 1864

页数：6

共 13 条

[1] ISOLATION AND STRUCTURE ELUCIDATION OF CHAETOCIN [J].