NEURONS OF THE PERIPHERAL NERVOUS-SYSTEM EXPRESS THYMIDINE PHOSPHORYLASE

被引：12

作者：

ECCLESTON, PA ^{[1
]}

FUNA, K ^{[1
]}

HELDIN, CH ^{[1
]}

机构：

[1] LUDWIG INST CANC RES,CTR BIOMED,S-75124 UPPSALA,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1995年 / 192卷 / 02期

关键词：

SENSORY NEURONS; PERIPHERAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR;

D O I：

10.1016/0304-3940(95)11622-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Platelet-derived endothelial cell growth factor (PD-ECGF) is an angiogenic factor which recently has been shown to be identical to thymidine phosphorylase. We describe here, high levels of expression of PD-ECGF/thymidine phosphorylase in neurons of the peripheral nervous system (PNS) but very little in the central nervous system (CNS). Monoclonal and polyclonal antibodies were used for the staining of sections of dorsal root ganglia, sympathetic cervical ganglia and the enteric plexus as well as the brain and spinal cord. In addition, in situ hybridisation confirmed the results of immunohistochemistry. The possible role of thymidine phosphorylase in the PNS is discussed.

引用

页码：137 / 141

页数：5

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