TRISOMY-20 IS A PRIMARY CHROMOSOME ABERRATION IN DESMOID TUMORS

被引：20

作者：

MERTENS, F

WILLEN, H

RYDHOLM, A

BROSJO, O

CARLEN, B

MITELMAN, F

MANDAHL, N

机构：

[1] UNIV LUND HOSP,DEPT PATHOL,S-22185 LUND,SWEDEN

[2] UNIV LUND HOSP,DEPT ORTHOPED,S-22185 LUND,SWEDEN

[3] KAROLINSKA HOSP,DEPT ORTHOPED,ONCOL SECT,S-10401 STOCKHOLM,SWEDEN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1995年 / 63卷 / 04期

关键词：

D O I：

10.1002/ijc.2910630412

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis revealed trisomy 20 in 4 desmoid tumors: in 2 cases as the sole aberration, in 1 together with +X, -Y and -13 and in 1 with +8 and a supernumerary marker chromosome. Our findings indicate that gain of chromosome 20 is an early event in the development of a large subset of desmoid tumors and that it is as frequent as +8, the only consistent chromosomal change previously reported in this tumor type. The non-random occurrence of trisomies 8 and 20 in desmoid tumors indicates shared pathogenetic mechanisms with infantile fibrosarcoma, a fibrous tissue tumor characterized by various combinations of trisomies for chromosomes 8, 11, 17 and 20. (C) 1995 Wiley-Liss, Inc.

引用

页码：527 / 529

页数：3

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