EFFECT OF PH AND SODIUM METABISULPHITE ON STABILITY OF PHYSOSTIGMINE SULPHATE SOLUTIONS TO HEAT AND IONIZING RADIATION

被引：11

作者：

FLETCHER, G

DAVIES, DJG

机构：

[1] Pharmaceutics Group, School of Pharmacy, Bath University of Technology, Ashley Down

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / S 20卷

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09870.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A method which assays the alkaloid in the presence of its breakdown products has been used to investigate the effects of heating and exposure to ionizing radiations on the degradation kinetics of aqueous physostigmine solutions. Maximum stability at 90***° is between pH 2·2 and 3·0. Sodium metabisulphite retards the degradation of physostigmine when exposed to gamma irradiation, but has no effect on the degradation by heat. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：S108 / &