A 2ND NONRANDOM TRANSLOCATION, DER(16)T(1-16)(Q21-Q13), IN EWING SARCOMA AND PERIPHERAL NEUROECTODERMAL TUMOR

被引：74

作者：

DOUGLASS, EC

ROWE, ST

VALENTINE, M

PARHAM, D

MEYER, WH

THOMPSON, EI

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT PATHOL & LAB MED, MEMPHIS, TN 38101 USA

[2] UNIV TENNESSEE, CTR HLTH SCI,COLL MED,DEPT PEDIAT, DIV HEMATOL ONCOL, MEMPHIS, TN 38163 USA

[3] UNIV TENNESSEE, CTR HLTH SCI, COLL MED, DEPT PATHOL, MEMPHIS, TN 38163 USA

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 53卷 / 2-3期

关键词：

D O I：

10.1159/000132901

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The majority of Ewing sarcomas and peripheral neuroectodermal tumors (PNET) that have been karyotyped contain a specific translocation. t(ll:22)(q23:ql 1). We report here a second nonrandom translocation. der(l6)t(I;16)(q21;q 13). in 2 of 20 cases of Ewing sarcoma (seven previously unreported) and 2 of 7 cases of PNET (all previously unreported). All cases with this translocation also contained the l(11:22). Comparison of C-band-ing patterns in tumor and peripheral lymphocyte karyotypes in one case indicated that the likely breakpoints were lq21 and I6ql3. The presence of this translocation in cell lines will enable further investigation of the molecular events important in the pathogenesis of Ewing sarcoma and PNET. © 1990 S. Karger AG, Basel.

引用

页码：87 / 90

页数：4

共 30 条

[1] TRANSLOCATION INVOLVING CHROMOSOME-22 IN EWINGS-SARCOMA - A CYTOGENETIC STUDY OF 4 FRESH TUMORS [J].

AURIAS, A ;

RIMBAUT, C ;

BUFFE, D ;

ZUCKER, JM ;

MAZABRAUD, A .

CANCER GENETICS AND CYTOGENETICS, 1984, 12 (01) :21-25

[2]

AYRAUD N, 1977, ANN GENET-PARIS, V20, P171

[3] PATTERNS OF THE EARLY, GROSS CHROMOSOMAL CHANGES IN MALIGNANT HUMAN GLIOMAS [J].

BIGNER, SH ;

MARK, J ;

MAHALEY, MS ;

BIGNER, DD .

HEREDITAS, 1984, 101 (01) :103-113

[4]

BUDARF M, 1989, AM J HUM GENET, V45, P128

[5] THE CELLULAR HOMOLOG OF THE TRANSFORMING GENE OF SKV AVIAN RETROVIRUS MAPS TO HUMAN-CHROMOSOME REGION 1Q22-]Q24 [J].

CHAGANTI, RSK ;

BALAZS, I ;

JHANWAR, SC ;

MURTY, VVVS ;

KODURU, PRK ;

GRZESCHIK, KH ;

STAVNEZER, E .

CYTOGENETICS AND CELL GENETICS, 1986, 43 (3-4) :181-186

[6] A SPECIFIC CHROMOSOMAL ABNORMALITY IN RHABDOMYOSARCOMA [J].

DOUGLASS, EC ;

VALENTINE, M ;

ETCUBANAS, E ;

PARHAM, D ;

WEBBER, BL ;

HOUGHTON, PJ ;

GREEN, AA .

CYTOGENETICS AND CELL GENETICS, 1987, 45 (3-4) :148-155

[7]

DOUGLASS EC, 1986, J NATL CANCER I, V77, P1211

[8] COMPARISON OF CONSTITUTIONAL AND TUMOR-ASSOCIATED 11-22 TRANSLOCATIONS - NONIDENTICAL BREAKPOINTS ON CHROMOSOME-11 AND CHROMOSOME-22 [J].

GRIFFIN, CA ;

MCKEON, C ;

ISRAEL, MA ;

GEGONNE, A ;

GHYSDAEL, J ;

STEHELIN, D ;

DOUGLASS, EC ;

GREEN, AA ;

EMANUEL, BS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) :6122-6126

[9]

HAAS OA, 1987, CANCER, V60, P2219, DOI 10.1002/1097-0142(19871101)60:9<2219::AID-CNCR2820600919>3.0.CO

[10]

2-Z

← 1 2 3 →