ANTINEOPLASTIC AGENTS SERIES .225. ISOLATION AND STRUCTURE OF BRYOSTATIN-14 AND BRYOSTATIN-15

被引：47

作者：

PETTIT, GR ^{[1
]}

GAO, F ^{[1
]}

SENGUPTA, D ^{[1
]}

COLL, JC ^{[1
]}

HERALD, CL ^{[1
]}

DOUBEK, DL ^{[1
]}

SCHMIDT, JM ^{[1
]}

VANCAMP, JR ^{[1
]}

RUDLOE, JJ ^{[1
]}

NIEMAN, RA ^{[1
]}

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

来源：

TETRAHEDRON | 1991年 / 47卷 / 22期

关键词：

D O I：

10.1016/S0040-4020(01)80873-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Further investigation of constituents from the marine bryozoan Bugula neritina employing new 1,000 kg recollections from the Gulf of Mexico and Eastern Pacific Ocean (California) has led to isolation and structural determination of two previously undetected members of the bryostatin (1-13) series, bryostatins 14 (14) and 15 (15). Structural analyses were conducted primarily with high field (400 MHz) NMR and high resolution mass spectral techniques. Both new bryostatins significantly inhibited growth of the P388 lymphocytic leukemia.

引用

页码：3601 / 3610

页数：10

共 29 条

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