ALTERATIONS IN [SPIPERONE-H-3 BINDING IN HUMAN CAUDATE-NUCLEUS, SUBSTANTIA NIGRA AND FRONTAL-CORTEX IN THE SHYDRAGER SYNDROME AND PARKINSONS-DISEASE

被引:54
作者
QUIK, M
SPOKES, EG
MACKAY, AVP
BANNISTER, R
机构
[1] UNIV CAMBRIDGE,MRC,NEUROCHEM PHARMACOL UNIT,CAMBRIDGE CB2 2QD,ENGLAND
[2] NATL HOSP,LONDON WC1N 3BG,ENGLAND
关键词
D O I
10.1016/0022-510X(79)90021-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
[3H]Spiperone binding was investigated in the caudate nucleus, substantia nigra (s.nigra) and frontal cortex of control subjects and of patients with Parkinson's disease and the Shy-Drager syndrome. Binding sites for [3H]spiperone were interpreted as dopamine receptors in caudate and s. nigra, and as 5-hydroxytryptamine (5-HT) receptors in frontal cortex. Scatchard analysis showed that the Bmax (maximal number of binding sites) in caudate was similar in the 3 groups, whereas in s. nigra the Bmax was reduced by approximately 60% in both Parkinson's disease and Shy-Drager syndrome. The dissociation constant (Kd) for [3H]spiperone binding in s. nigra was similar in the 3 groups. In caudate nucleus, the Kd was similar in control and Parkinson groups; however, there was a significant increase in the dissociation constant in the caudate nucleus from cases of Shy-Drager syndrome. No differences in binding characteristics were observed in the frontal cortex. These results are taken to reflect a loss of dopamine receptor sites in the s. nigra in both Parkinson's disease and Shy-Drager syndrome, and a reduced affinity of dopamine receptor sites in the caudate nucleus in Shy-Drager syndrome. © 1979.
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页码:429 / 437
页数:9
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