KONINGIC ACID (HEPTELIDIC ACID) INHIBITION OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES FROM VARIOUS SOURCES

被引：40

作者：

KATO, M ^{[1
]}

SAKAI, K ^{[1
]}

ENDO, A ^{[1
]}

机构：

[1] TOKYO NOKO UNIV,DEPT APPL BIOL SCI,FUCHU,TOKYO 183,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1120卷 / 01期

关键词：

GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE INHIBITOR; KONINGIC ACID;

D O I：

10.1016/0167-4838(92)90431-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Koningic acid is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which binds to the cysteine residue at the active site. We have determined sensitivity of GAPDHs in comparison with their amino acid sequences. It was found that koningic acid sensitivity of GAPDHs is highly dependent on the sequences of the S-loop domain of the enzyme.

引用

页码：113 / 116

页数：4

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