ULTRASTRUCTURAL RELATIONS BETWEEN BETA-ADRENERGIC RECEPTORS AND CATECHOLAMINERGIC NEURONS

被引:49
作者
AOKI, C [1 ]
PICKEL, VM [1 ]
机构
[1] CORNELL UNIV,MED CTR,COLL MED,DEPT NEUROL & NEUROSCI,DIV NEUROBIOL,NEW YORK,NY 10021
关键词
BETA-ADRENERGIC RECEPTORS; BETA-ADRENOCEPTORS; ASTROCYTES; NUCLEUS OF THE SOLITARY TRACT; AREA POSTREMA; VISUAL CORTEX; CATECHOLAMINES; ULTRASTRUCTURE; BLOOD-BRAIN BARRIER; SYNAPSE; CIRCUMVENTRICULAR ORGAN;
D O I
10.1016/0361-9230(92)90055-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We performed dual electron microscopic immunocytochemistry to determine the precise cellular relations between beta-adrenergic receptors (beta-AR) and catecholaminergic terminals within adult rat brains. An antibody, beta-AR404, against a peptide corresponding to the C-terminus of the hamster lung beta-AR (beta-2 subtype) together with an anti-tyrosine hydroxylase (TH), a catecholaminergic marker, were used. Results show predominant labeling for beta-AR404 within small astrocytic processes (beta-A). This is in sharp contrast to earlier results which showed neuronal labeling when using antibodies against the third intracellular loop of the receptor and of neurons-plus-astrocytes labeled using antibodies against the whole beta-AR molecule. beta-A within visual cortex and nuclei of the solitary tracts frequently contacted blood vessel basement membrane and TH-immunoreactive terminals. TH-immunoreactive axons forming axo-axonic juxtapositions with non-TH terminals were also noted to be surrounded by beta-A. In the area postrema, a brain region lacking a blood-brain barrier, few beta-A occurred adjacent to TH-immunoreactive terminals or elsewhere. Thus, 1) catecholamines may act beyond morphologically identifiable synapses, 2) beta-A may mediate interactions between catecholamines and other transmitters; 3) there may be substantial heterogeneity in the structure or the conformation of the beta-AR protein between neurons and glia or across CNS regions.
引用
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页码:257 / 263
页数:7
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