DIETARY SUPPLEMENTATION WITH L-ARGININE AMELIORATES THE PROGRESSION OF RENAL-DISEASE IN RATS WITH SUBTOTAL NEPHRECTOMY

被引:122
作者
REYES, AA
PURKERSON, ML
KARL, I
KLAHR, S
机构
[1] WASHINGTON UNIV,SCH MED,DIV RENAL,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DIV METAB,ST LOUIS,MO 63110
[3] WASHINGTON UNIV,JEWISH HOSP ST LOUIS,MED CTR,DEPT INTERNAL MED,ST LOUIS,MO 63110
关键词
CHRONIC RENAL DISEASE; L-ARGININE; GLOMERULOSCLEROSIS; ENDOTHELIUM-DERIVED RELAXING FACTOR;
D O I
10.1016/S0272-6386(12)80546-4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We studied the effect of dietary supplementation with l-arginine for 6 weeks on the progression of renal disease in female Sprague-Dawley rats subjected to sham-operation (groups 1 and 2) or surgical ablation of 85% to 90% of the total renal mass (groups 3 and 4). All rats were fed a standard rat chow containing 22.8% protein. Rats in groups 1(n = 5) and 3 (n = 9) served as controls and drank tap water ad libitum. Rats in groups 2 (n = 6) and 4 (n = 6) drank tap water supplemented with 1 % l-arginine. Rats in groups 1 and 2 had similar values for glomerular and tubular function and serum chemistries 6 weeks after sham-operation. Sham-operated rats given l-arginine had significantly greater urine urea excretion than similar rats drinking tap water. Rats with subtotal nephrectomy (groups 3 and 4) had a significantly higher blood pressure, greater proteinuria, and a significantly lower plasma albumin than sham-operated rats (groups 1 and 2). Rats with remnant kidneys given 1 % l-arginine (group 4) had significantly greater values for glomerular filtration rate (GFR) and P-amino hippurate (PAH) clearance than similar rats given tap water (group 3), despite comparable levels of systemic blood pressure, hematocrit, body weight, plasma chemistries, including l-arginine, and urine chemistries, except urea excretion. The remnant kidney of rats given L-arginine (group 4) had a greater number of normal or minimally abnormal glomeruli and fewer interstitial changes than that of rats given tap water (group 3). The beneficial effect of l-arginine was not accompanied by changes in systemic blood pressure or lipid profile, and was not associated with changes in protein or caloric intake. © 1992, National Kidney Foundation. All rights reserved. All rights reserved.
引用
收藏
页码:168 / 176
页数:9
相关论文
共 20 条
[1]  
ALFREY AC, 1988, AM J CLIN NUTR, V47, P153
[2]   THERAPEUTIC ADVANTAGE OF CONVERTING ENZYME-INHIBITORS IN ARRESTING PROGRESSIVE RENAL-DISEASE ASSOCIATED WITH SYSTEMIC HYPERTENSION IN THE RAT [J].
ANDERSON, S ;
RENNKE, HG ;
BRENNER, BM .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (06) :1993-2000
[3]   CONTROL OF GLOMERULAR HYPERTENSION LIMITS GLOMERULAR INJURY IN RATS WITH REDUCED RENAL MASS [J].
ANDERSON, S ;
MEYER, TW ;
RENNKE, HG ;
BRENNER, BM .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (02) :612-619
[4]  
CARG VC, 1989, J CLIN INVEST, V83, P1774
[5]   MUSCLE PROTEIN-TURNOVER - EFFECTS OF EXERCISE TRAINING AND RENAL-INSUFFICIENCY [J].
DAVIS, TA ;
KARL, IE ;
TEGTMEYER, ED ;
OSBORNE, DF ;
KLAHR, S ;
HARTER, HR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (03) :E337-E345
[6]   RELATIVE IMPORTANCE OF KIDNEY AND LIVER IN SYNTHESIS OF ARGININE BY RAT [J].
FEATHERSTON, WR ;
ROGERS, QR ;
FREEDLAND, RA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1973, 224 (01) :127-129
[7]   EFFECTS OF REDUCED RENAL MASS AND DIETARY-PROTEIN INTAKE ON AMINO-ACID RELEASE AND GLUCOSE-UPTAKE BY RAT MUSCLE INVITRO [J].
HARTER, HR ;
KARL, IE ;
KLAHR, S ;
KIPNIS, DM .
JOURNAL OF CLINICAL INVESTIGATION, 1979, 64 (02) :513-523
[8]   EFFECT OF DIETARY LIPIDS ON RENAL-FUNCTION IN RATS WITH SUBTOTAL NEPHRECTOMY [J].
HEIFETS, M ;
MORRISSEY, JJ ;
PURKERSON, ML ;
MORRISON, AR ;
KLAHR, S .
KIDNEY INTERNATIONAL, 1987, 32 (03) :335-341
[9]   DIETARY TRYPTOPHAN SUPPLEMENTATION PREVENTS PROTEINURIA IN THE 7/8 NEPHRECTOMIZED RAT [J].
KAYSEN, GA ;
KROPP, J .
KIDNEY INTERNATIONAL, 1983, 23 (03) :473-479
[10]  
KLAHR S, 1988, NEW ENGL J MED, V318, P1657