THE RELATIONSHIP BETWEEN THE DEGRADATION OF PROSTACYCLIN IN BLOOD AND ANTIPLATELET DRUG EFFECTS IN PATIENTS WITH ATHEROSCLEROSIS

被引：4

作者：

AKOPOV, SE

GABRIELIAN, ES

机构：

[1] Department of Pharmacology, Yerevan Medical Institute, Yerevan

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 33卷 / 11期

关键词：

D O I：

10.1002/j.1552-4604.1993.tb01941.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Blood and plasma from 109 patients with atherosclerosis and 70 healthy volunteers were tested to study the rate of prostacyclin (PGI2) hydrolysis. It has been reported that patients with atherosclerosis have the enhanced velocity of PGI2 degradation. The increase in the velocity was more marked in blood than in plasma. The significant negative correlation between antiaggregation effects of pentoxifylline, nifedipine, and dipyridamole and the velocity of PGI2 degradation in the patients was found. These data suggest that the increase of PGI2 biosynthesis by the drugs studied can enhance their antiaggregation effect if processes of PGI2 degradation in blood are not accelerated.

引用

页码：1048 / 1051

页数：4

共 12 条

[1]

CHEN YC, 1982, LANCET, V8241, P267

[2]

GABRIELIAN ES, 1984, 9TH JUPHAR INT C PHA, V3, P7

[3] EFFECTS OF INTRAVENOUS ADMINISTRATION OF A CALCIUM-ANTAGONIST ON PROSTAGLANDINS AND THROMBOXANE IN PLASMA AND URINE IN HUMANS [J].