5-YEAR TREATMENT OF THE CHRONIC SYNDROME OF INAPPROPRIATE SECRETION OF ADH WITH ORAL UREA

被引：22

作者：

DECAUX, G ^{[1
]}

PROSPERT, F ^{[1
]}

PENNINCKX, R ^{[1
]}

NAMIAS, B ^{[1
]}

SOUPART, A ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS,ERASME UNIV HOSP,DEPT INTERNAL MED,HYDROMINERAL METAB RES UNIT,B-1050 BRUSSELS,BELGIUM

来源：

NEPHRON | 1993年 / 63卷 / 04期

关键词：

HYPONATREMIA; ANTIDIURETIC HORMONE; UREA; OSMOTIC DIURESIS;

D O I：

10.1159/000187255

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a patient with an idiopathic syndrome of inappropriate secretion of ADH for more than 6 years. Water restriction was effective only during hospital care but was socially difficult to maintain at home, so that the patient presented frequent symptoms of water intoxication. Normal natremia was also obtained with a high salt intake (9 g/day) but this induced leg edema, mild dyspnea and gastric intolerance. The patient was however successfully treated for more than 5 years without any side effects with oral urea (30 g/day) allowing her a normal fluid intake (1-1.5 liters/day). Oral urea, even during long periods, is a safe and effective therapeutic approach for patients with chronic SIADH which is not controlled by water restriction alone.

引用

页码：468 / 470

页数：3

共 15 条

[1] SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC HORMONE [J].