TERBINAFINE-ASSOCIATED HEPATIC-INJURY

被引：30

作者：

VANTWOUT, JW

HERRMANN, WA

DEVRIES, RA

STRICKER, BHC

机构：

[1] BRONOVO HOSP,DEPT INTERNAL MED & DERMATOL,THE HAGUE,NETHERLANDS

[2] RIJNSTATE HOSP,DEPT INTERNAL MED,ARNHEM,NETHERLANDS

[3] ACAD HOSP ROTTERDAM DIJKZIGT,DEPT INTERNAL MED 2,ROTTERDAM,NETHERLANDS

[4] NETHERLANDS CTR MONITORING ADVERSE RESCT DRUGS,RIJSWIJK,NETHERLANDS

来源：

JOURNAL OF HEPATOLOGY | 1994年 / 21卷 / 01期

关键词：

ANTIFUNGALS; HEPATOTOXICITY; ONYCHOMYCOSIS; TERBINAFINE;

D O I：

10.1016/S0168-8278(94)80146-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepa titis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but in the second patient alkaline phosphatase, aminotransferase and gamma-glutamyl transferase levels have remained elevated (follow up 3 months after cessation of treatment with terbinafine). Most likely, the terbinafine-associated hepatic injury in these patients was caused by an idiosyncratic rather than a direct hepatotoxic reaction. (C) Journal of Hepatology.

引用

页码：115 / 117

页数：3

共 8 条

[1] SHORT-TERM TREATMENT OF DERMATOPHYTE ONYCHOMYCOSIS WITH TERBINAFINE [J].