EFFECTS OF A NOVEL MELATONIN ANALOG ON CIRCADIAN-RHYTHMS OF BODY-TEMPERATURE AND ACTIVITY IN YOUNG, MIDDLE-AGED, AND OLD RATS

被引：33

作者：

KOSTERVANHOFFEN, GC

MIRMIRAN, M

BOS, NPA

WITTING, W

DELAGRANGE, P

GUARDIOLALEMAITRE, B

机构：

[1] NETHERLANDS INST BRAIN RES, 1105 AZ AMSTERDAM, NETHERLANDS

[2] INST RECH INT SERVIER, F-92415 COURBEVOIE, FRANCE

来源：

NEUROBIOLOGY OF AGING | 1993年 / 14卷 / 06期

关键词：

CIRCADIAN RHYTHMS; BODY TEMPERATURE; ACTIVITY; SLEEP; AGING; MELATONIN; SUPRACHIASMATIC NUCLEUS; PINEAL GLAND;

D O I：

10.1016/0197-4580(93)90040-I

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Circadian rhythms of body temperature and activity were recorded in young, middle-aged, and old rats. A new melatonin analog, S20242, was administered daily around the onset of darkness for a 2-week period. Compared to the young animals, there was a significant age-related reduction in the amplitude and stability of body temperature and activity in both the middle-aged and old rats. In these two groups there was an improvement of the circadian rhythm of body temperature as a result of daily application of the melatonin analog.

引用

页码：565 / 569

页数：5

共 55 条

[1] SLEEP FRAGMENTATION IN PATIENTS FROM A NURSING-HOME [J].