IGG SUBCLASS LEVELS IN PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：14

作者：

COPSON, ER ^{[1
]}

ELLIS, BA ^{[1
]}

WESTWOOD, NB ^{[1
]}

MAJUMDAR, G ^{[1
]}

机构：

[1] UNITED MED & DENT SCH,DIV HAEMATOL,LONDON SE1 7EH,ENGLAND

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 14卷 / 5-6期

关键词：

IG SUBCLASS; B-CLL; CHRONIC LYMPHOCYTIC LEUKEMIA;

D O I：

10.3109/10428199409049706

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with B-cell chronic lymphocytic leukaemia (BCLL) have low levels of serum IgG. In order to determine if this is a pan IgG deficiency or a selective suppression of one or more IgG subclasses, levels of IgG 1, 2, 3 and 4 in nine BCLL patients were determined and compared to those of nine age and sex matched controls. No significant differences were found in the levels of IgG1 and IgC2, but the patients were found to have significantly lower levels of IgG3 (p < 0.05) and IgG4 (p < 0.05). Selective deficiencies of these isotypes may explain the particular pattern of infection seen in BCLL patients.

引用

页码：471 / 473

页数：3

共 12 条

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