DIFFERENTIAL INDUCTION OF BRAIN, LUNG AND LIVER NITRIC-OXIDE SYNTHASE BY ENDOTOXIN IN THE RAT

被引：408

作者：

KNOWLES, RG

MERRETT, M

SALTER, M

MONCADA, S

机构：

[1] Wellcome Research Laboratories, Beckenham, Kent

来源：

BIOCHEMICAL JOURNAL | 1990年 / 270卷 / 03期

关键词：

D O I：

10.1042/bj2700833

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.

引用

页码：833 / 836

页数：4

共 28 条

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