MECHANISMS INVOLVED IN THE PITUITARY DESENSITIZATION INDUCED BY GONADOTROPIN-RELEASING-HORMONE AGONISTS

被引:17
作者
UEMURA, T
YANAGISAWA, T
SHIRASU, K
MATSUYAMA, A
MINAGUCHI, H
机构
关键词
PITUITARY DESENSITIZATION; GONADOTROPIN-RELEASING HORMONE AGONIST; LUTEINIZING HORMONE; LUTEINIZING HORMONE BETA-MESSENGER RIBONUCLEIC ACID; GONADOTROPIN-RELEASING HORMONE RECEPTOR;
D O I
10.1016/S0002-9378(11)91676-7
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: We investigated the mechanisms of desensitization induced by gonadotropin-releasing hormone agonist in the pituitary. STUDY DESIGN: Effects of gonadotropin-releasing hormone agonist on the pituitary were studied in vitro and in vivo in the rat. In the clinical study serum luteinizing hormone was measured by radioimmunoassay with a polyclonal luteinizing hormone antibody (luteinizing hormone-radioimmunoassay) and by immunoradiometric assay with monoclonal luteinizing hormone antibodies (luteinizing hormone-immunoradiometric assay) during gonadotropin-releasing hormone agonist treatment. RESULTS: In the in vitro study bead-attached pituitary cells that were desensitized with a continuous infusion of 10(-7) mol/L gonadotropin-releasing hormone responded to 50 mmol/L K+. In the in vivo study gonadotropin-releasing hormone binding sites and rat luteinizing hormone beta-messenger ribonucleic acid in the pituitary decreased during gonadotropin-releasing hormone agonist treatment, but serum levels of rat luteinizing hormone did not decrease. In addition, a disparity between luteinizing hormone-radioimmunoassay and luteinizing hormone-immunoradiometric assay was demonstrated during gonadotropin-releasing hormone agonist treatment. CONCLUSION: Pituitary desensitization in response to gonadotropin-releasing hormone agonist may not be wholly receptor mediated and a nonreceptor process may be involved.
引用
收藏
页码:283 / 291
页数:9
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