HIV-INFECTION IS ACTIVE AND PROGRESSIVE IN LYMPHOID-TISSUE DURING THE CLINICALLY LATENT STAGE OF DISEASE

被引:1655
作者
PANTALEO, G
GRAZIOSI, C
DEMAREST, JF
BUTINI, L
MONTRONI, M
FOX, CH
ORENSTEIN, JM
KOTLER, DP
FAUCI, AS
机构
[1] UNIV ANCONA,DEPT INTERNAL MED,I-60020 ANCONA,ITALY
[2] YALE UNIV,SCH MED,DEPT NEUROPATHOL,NEW HAVEN,CT 06510
[3] GEORGE WASHINGTON UNIV,DEPT PATHOL,WASHINGTON,DC 20037
[4] ST LUKES ROOSEVELT HOSP,NEW YORK,NY 10025
关键词
D O I
10.1038/362355a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
PRIMARY infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms1-3. This in turn is followed by a prolonged period of clinical latency. During this period there is little, if any, detectable viraemia, the numbers of infected cells in the blood are very low, and it is extremely difficult to demonstrate virus expression in these cells4. We have analysed viral burden and levels of virus replication simultaneously in the blood and lymphoid organs of the same individuals at various stages of HIV disease. Here we report that in early-stage disease there is a dichotomy between the levels of viral burden and virus replication in peripheral blood versus lymphoid organs. HIV disease is active in the lymphoid tissue throughout the period of clinical latency, even at times when minimal viral activity is demonstrated in blood.
引用
收藏
页码:355 / 358
页数:4
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