HEMODYNAMIC-EFFECTS OF A NOVEL HYPOTENSIVE PEPTIDE, HUMAN ADRENOMEDULLIN, IN RATS

被引：289

作者：

ISHIYAMA, Y ^{[1
]}

KITAMURA, K ^{[1
]}

ICHIKI, Y ^{[1
]}

NAKAMURA, S ^{[1
]}

KIDA, O ^{[1
]}

KANGAWA, K ^{[1
]}

ETO, T ^{[1
]}

机构：

[1] NATL CARDIOVASC CTR,RES INST,SUITA,OSAKA 565,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 241卷 / 2-3期

关键词：

ADRENOMEDULLIN; CAMP; BLOOD PRESSURE (RAT); VASODILATION;

D O I：

10.1016/0014-2999(93)90214-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The hemodynamic effects of human adrenomedullin were investigated in anesthetized Wistar rats. Intravenous administration of adrenomedullin (1.0 nmol/kg) caused a rapid and marked reduction in mean blood pressure associated with a decrease in total peripheral resistance. This reduction in mean blood pressure was closely correlated with the decrease in total peripheral resistance. These findings indicate that human adrenomedullin is a potent vasodilator and may have some role in the regulation of blood pressure.

引用

页码：271 / 273

页数：3

共 12 条

[1] DIPETTE DJ, 1987, HYPERTENSION S3, V9, P111
[2] ATTENUATION OF THE BARORECEPTOR REFLEX BY GENERAL ANESTHETIC AGENTS IN THE NORMOTENSIVE RAT
FLUCKIGER, JP
SONNAY, M
BOILLAT, N
ATKINSON, J
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 109 (01) : 105 - 109
[3] REGIONAL HEMODYNAMIC-EFFECTS OF CALCITONIN GENE-RELATED PEPTIDE
GARDINER, SM
COMPTON, AM
BENNETT, T
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (02): : R332 - R338
[4] THE EFFECTS OF HUMAN ATRIAL 28-AMINO ACID PEPTIDE ON SYSTEMIC AND RENAL HEMODYNAMICS IN ANESTHETIZED RATS
HIRATA, Y
ISHII, M
SUGIMOTO, T
MATSUOKA, H
SUGIMOTO, T
KANGAWA, K
MATSUO, H
[J]. CIRCULATION RESEARCH, 1985, 57 (04) : 634 - 639
[5] ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA
KITAMURA, K
KANGAWA, K
KAWAMOTO, M
ICHIKI, Y
NAKAMURA, S
MATSUO, H
ETO, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) : 553 - 560
[6] SELECTIVE ACTIVATION OF THE B-NATRIURETIC PEPTIDE RECEPTOR BY C-TYPE NATRIURETIC PEPTIDE (CNP)
KOLLER, KJ
LOWE, DG
BENNETT, GL
MINAMINO, N
KANGAWA, K
MATSUO, H
GOEDDEL, DV
[J]. SCIENCE, 1991, 252 (5002) : 120 - 123
[7] CALCITONIN GENE-RELATED PEPTIDE STIMULATES CYCLIC-AMP FORMATION IN RAT AORTIC SMOOTH-MUSCLE CELLS
KUBOTA, M
MOSELEY, JM
BUTERA, L
DUSTING, GJ
MACDONALD, PS
MARTIN, TJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (01) : 88 - 94
[8] CYCLIC GUANOSINE-MONOPHOSPHATE AS A MEDIATOR OF VASODILATION
MURAD, F
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (01) : 1 - 5
[9] Murad F, 1990, PHARMACOL BASIS THER, P764
[10] INVOLVEMENT OF SYMPATHETIC-NERVES IN CARDIOSUPPRESSIVE EFFECTS OF ALPHA-HUMAN ATRIAL NATRIURETIC POLYPEPTIDE (ALPHA-HANP) IN ANESTHETIZED RATS
SASAKI, A
KIDA, O
KANGAWA, K
MATSUO, H
TANAKA, K
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 120 (03) : 345 - 349

← 1 2 →