AN ENZYME-CATALYZED SYNTHESIS OF NATURAL ALPHA-TOCOPHEROL

被引：28

作者：

MIZUGUCHI, E ^{[1
]}

TAKEMOTO, M ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA,SCH PHARMACEUT SCI,52-1 YADA,SHIZUOKA 422,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 09期

关键词：

D O I：

10.1016/S0957-4166(00)82239-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The natural alpha-tocopherol was synthesized by enzyme-catalyzed enantioselective hydrolysis. The unnatural enantiomer as a by-product was also converted to natural alpha-tocopherol by racemization and repeated enzyme-catalyzed hydrolysis.

引用

页码：1961 / 1964

页数：4

共 10 条

[1] BIOLOGICAL ACTIVITY OF AN L-EPIMER OF D-ALPHA-TOCOPHERYL ACETATE
AMES, SR
NELAN, DR
ROBESON, CD
LUDWIG, MI
[J]. BIOCHEMISTRY, 1963, 2 (01) : 188 - &
[2] EBIKE H, 1991, TETRAHEDRON LETT, V32, P5805
[3] The steric proportions of alpha-tocopherol and further analysis of lower homologues of alpha-tocopherol
Karrer, P
Koenig, H
Ringier, BH
Salomon, H
[J]. HELVETICA CHIMICA ACTA, 1939, 22 : 1139 - 1145
[4] KIJIMA S, 1985, Patent No. 604183
[5] BIOPOTENCY OF ALPHA-TOCOPHEROLS AS DETERMINED BY CURATIVE MYOPATHY BIOASSAY IN THE RAT
MACHLIN, LJ
GABRIEL, E
BRIN, M
[J]. JOURNAL OF NUTRITION, 1982, 112 (07) : 1437 - 1440
[6] LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF N-ACYLOXYMETHYL GROUPS IN ORGANIC-SOLVENT - SYNTHESES OF CHIRAL 5,5-DISUBSTITUTED 1-METHYLBARBITURATES
MURATA, M
ACHIWA, K
[J]. TETRAHEDRON LETTERS, 1991, 32 (46) : 6763 - 6766
[7] NIKI E, OXYGEN RADICALS BIOL
[8] ISOLATION OF AN L-EPIMER OF NATURAL D-ALPHA-TOCOPHEROL
ROBESON, CD
NELAN, DR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (16) : 3196 - &
[9] ROBESON CD, 1964, Patent No. 3153040
[10] UBER DIE CHEMIE DES VITAMINS E .1. DIE UMKEHRUNG DER KONFIGURATION AM KOHLENSTOFFATOM 2 VON NATURLICHEM (2 R, 4'R, 8'R)-ALPHA-TOCOPHEROL
SCHUDEL, P
RUEGG, R
METZGER, J
ISLER, O
MAYER, H
[J]. HELVETICA CHIMICA ACTA, 1963, 46 (01) : 333 - &

← 1 →