LIPID-PEROXIDATION IN RATS INTOXICATED WITH 3-NITROPROPIONIC ACID

被引:36
作者
FU, YT [1 ]
HE, FS [1 ]
ZHANG, SL [1 ]
ZHANG, JS [1 ]
机构
[1] CHINESE ACAD PREVENT MED,INST OCCUPAT MED,BEIJING 100050,PEOPLES R CHINA
关键词
D O I
10.1016/0041-0101(94)00173-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Using an electron spin resonance technique, free radical signals were observed to be increased in liver of rats 15, 30 and 45 min after orally dosing with 80 mg/kg 3-nitropropionic acid (3-NPA). Concentrations of 3-NPA from 595 to 2380 mg/litre enhanced the formation of adrenochrome from adrenaline in mitochondria and microsome suspensions of liver and brain. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) as well as the content of malonidialdehyde (MDA) were significantly increased in liver of rats dosed with 80 mg/kg 3-NPA. There was also a cerebral increase of activity of SOD and content of MDA. These results suggest that 3-NPA is able to produce lipid peroxidation both in vivo and in vitro.
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页码:327 / 331
页数:5
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