HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION - RELATIONSHIP OF RISK GROUP AND AGE TO RATE OF PROGRESSION TO AIDS

被引：79

作者：

OPERSKALSKI, EA

STRAM, DO

LEE, H

ZHOU, Y

DONEGAN, E

BUSCH, MP

STEVENS, CE

SCHIFF, ER

DIETRICH, SL

MOSLEY, JW

机构：

[1] UNIV SO CALIF, SCH MED, TRANSFUS SAFETY STUDY, LOS ANGELES, CA 90032 USA

[2] UNIV CALIF LOS ANGELES, LOS ANGELES, CA USA

[3] HUNTINGTON MEM HOSP, HEMOPHILIA CLIN, PASADENA, CA USA

[4] WAYNE STATE UNIV, DETROIT, MI USA

[5] UNIV MIAMI, MIAMI, FL USA

[6] AMER RED CROSS, BLOOD SERV, MIAMI, FL USA

[7] MT SINAI MED CTR, NEW YORK, NY USA

[8] CORNELL UNIV, MED CTR, NEW YORK, NY 10021 USA

[9] NEW YORK BLOOD CTR, NEW YORK, NY 10021 USA

[10] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO, CA USA

[11] IRWIN MEM BLOOD CTR, SAN FRANCISCO, CA USA

[12] ALTA BATES COMMUNITY HOSP, OAKLAND, CA USA

[13] PUGET SOUND BLOOD CTR, SEATTLE, WA USA

[14] NHLBI, BETHESDA, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 03期

关键词：

D O I：

10.1093/infdis/172.3.648

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII-treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.

引用

页码：648 / 655

页数：8

共 60 条

[1] RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA [J].

ALBERT, J ;

ABRAHAMSSON, B ;

NAGY, K ;

AURELIUS, E ;

GAINES, H ;

NYSTROM, G ;

FENYO, EM .

AIDS, 1990, 4 (02) :107-112

[2]

[Anonymous], 1992, AIDS, V6, P421

[3] HIV-INFECTION IN RECIPIENTS OF BLOOD PRODUCTS FROM DONORS WITH KNOWN DURATION OF INFECTION [J].

ASHTON, LJ ;

LEARMONT, J ;

LUO, K ;

WYLIE, B ;

STEWART, G ;

KALDOR, JM .

LANCET, 1994, 344 (8924) :718-720

[4] INCUBATION PERIODS FOR PEDIATRIC AIDS PATIENTS [J].

AUGER, I ;

THOMAS, P ;

DEGRUTTOLA, V ;

MORSE, D ;

MOORE, D ;

WILLIAMS, R ;

TRUMAN, B ;

LAWRENCE, CE .

NATURE, 1988, 336 (6199) :575-577

[5] AIDS INCUBATION IN 1891 HIV SEROCONVERTERS FROM DIFFERENT EXPOSURE GROUPS [J].

BIGGAR, RJ .

AIDS, 1990, 4 (11) :1059-1066

[6] THE INFLUENCE OF AGE ON THE LATENCY PERIOD TO AIDS IN PEOPLE INFECTED BY HIV THROUGH BLOOD-TRANSFUSION [J].

BLAXHULT, A ;

GRANATH, F ;

LIDMAN, K ;

GIESECKE, J .

AIDS, 1990, 4 (02) :125-129

[7] EPIDEMIOLOGIC BACKGROUND AND LONG-TERM COURSE OF DISEASE IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED BLOOD-DONORS IDENTIFIED BEFORE ROUTINE LABORATORY SCREENING [J].

BUSCH, MP ;

OPERSKALSKI, EA ;

MOSLEY, JW ;

STEVENS, CE ;

SCHIFF, ER ;

KLEINMAN, SH ;

LEE, H ;

LEE, M ;

HARRIS, M ;

KASPER, CK ;

NOWICKI, MJ ;

PIKE, MC ;

STRAM, D ;

ZHOU, Y ;

DIETRICH, SL ;

LUSHER, JM ;

FLETCHER, MA ;

ALEDORT, LM ;

HASSETT, J ;

HILGARTNER, MW ;

TAYLOR, PE ;

DONEGAN, E ;

KOERPER, MA ;

LEWIS, BH ;

GJERSET, GF ;

HOLLINGSWORTH, CG ;

NEMO, GJ ;

HOAK, J ;

ALTER, HJ ;

DALESSIO, DJ ;

GRADY, GF ;

HOLLAND, PV ;

ROSE, NR ;

SEEFF, LB ;

WITTES, J .

TRANSFUSION, 1994, 34 (10) :858-864

[8] EFFECT OF AGE AND EXPOSURE GROUP ON THE ONSET OF AIDS IN HETEROSEXUAL AND HOMOSEXUAL HIV-INFECTED PATIENTS [J].

CARRE, N ;

DEVEAU, C ;

BELANGER, F ;

BOUFASSA, F ;

PERSOZ, A ;

JADAND, C ;

ROUZIOUX, C ;

DELFRAISSY, JF ;

BUCQUET, D ;

DELLAMONICA, P ;

GALLAIS, H ;

DORMONT, J ;

LEFRERE, JJ ;

CASSUTO, JP ;

DUPONT, B ;

VITTECOQ, D ;

HERSON, S ;

GASTAUT, JA ;

SERENI, D ;

VILDE, JL ;

BRUCKER, G ;

KATLAMA, C ;

SOBEL, A ;

DUVAL, J ;

KAZATCHINE, M ;

LEBRAS, P ;

EVEN, P ;

GUILLEVIN, L .

AIDS, 1994, 8 (06) :797-802

[9]

COX DR, 1972, J R STAT SOC B, V34, P187

[10]

DIAZ R, 1994, TRANSFUSION, V34, pS46

← 1 2 3 4 5 6 →