Monte Carlo simulation of ageing: Beyond bit-string models

被引：12

作者：

Bernardes, AT ^{[1
]}

Stauffer, D ^{[1
]}

机构：

[1] UNIV FED OURO PRETO,INST CIENCIAS EXATAS & BIOL,DEPT FIS,BR-35400000 OURO PRETO,MG,BRAZIL

来源：

INTERNATIONAL JOURNAL OF MODERN PHYSICS C-PHYSICS AND COMPUTERS | 1995年 / 6卷 / 06期

关键词：

senescence; Monte Carlo; mutational meltdown; population genetic theory;

D O I：

10.1142/S0129183195000654

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

Penna's bit-string model of biological ageing due to the accumulation of deleterious mutations is generalized to allow for more than one disease per year. The results remain qualitatively unchanged except for a more complicated non-monotonic approach to equilibrium. We also look at ''mutational meltdown'', the extinction of the whole population if all mutations are deleterious and heritable, and why the Penna model can escape this extinction. No dependence on population size is found for mutational meltdown, with up to 10(8) individuals.

引用

页码：789 / 806

页数：18

共 35 条

[1] ANTAGONISTIC PLEIOTROPY, MUTATION ACCUMULATION, AND HUMAN GENETIC-DISEASE [J].

ALBIN, RL .

GENETICA, 1993, 91 (1-3) :279-286

[2]

[Anonymous], 1994, EVOLUTION AGE STRUCT, DOI [10.1017/CBO9780511525711, DOI 10.1017/CBO9780511525711]

[3]

BERNARDES AT, 1995, J PHYS I, V5, P1501, DOI 10.1051/jp1:1995213

[4] EVOLUTIONARY MECHANISMS OF SENESCENCE [J].

CHARLESWORTH, B .

GENETICA, 1993, 91 (1-3) :11-19

[5] MUTATION-SELECTION BALANCE AND THE EVOLUTIONARY ADVANTAGE OF SEX AND RECOMBINATION [J].

CHARLESWORTH, B .

GENETICS RESEARCH, 1990, 55 (03) :199-221

[6] THE EFFECT OF LINKAGE AND POPULATION-SIZE ON INBREEDING DEPRESSION DUE TO MUTATIONAL LOAD [J].

CHARLESWORTH, D ;

MORGAN, MT ;

CHARLESWORTH, B .

GENETICS RESEARCH, 1992, 59 (01) :49-61

[7] MUTATION ACCUMULATION IN FINITE OUTBREEDING AND INBREEDING POPULATIONS [J].

CHARLESWORTH, D ;

MORGAN, MT ;

CHARLESWORTH, B .

GENETICS RESEARCH, 1993, 61 (01) :39-56

[8] MUTATION ACCUMULATION IN FINITE POPULATIONS [J].

CHARLESWORTH, D ;

MORGAN, MT ;

CHARLESWORTH, B .

JOURNAL OF HEREDITY, 1993, 84 (05) :321-325

[9]

DASGUPTA S, 1994, J PHYS I, V4, P1563, DOI 10.1051/jp1:1994207

[10] SIMULATING THE VANISHING OF NORTHERN COD FISH [J].

DEOLIVEIRA, SM ;

PENNA, TJP ;

STAUFFER, D .

PHYSICA A, 1995, 215 (03) :298-304

← 1 2 3 4 →