PLACEBO-CONTROLLED ACUTE DOSAGE NALTREXONE STUDY IN YOUNG AUTISTIC-CHILDREN

被引：51

作者：

WILLEMSENSWINKELS, SHN

BUITELAAR, JK

WEIJNEN, FG

VANENGELAND, H

机构：

[1] UNIV UTRECHT,DEPT CHILD PSYCHIAT,3508 GA UTRECHT,NETHERLANDS

[2] UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,3508 GA UTRECHT,NETHERLANDS

来源：

PSYCHIATRY RESEARCH | 1995年 / 58卷 / 03期

关键词：

ETHOLOGY; BETA-ENDORPHIN; CORTISOL; ATTENTION; SOCIAL BEHAVIOR; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0165-1781(95)02749-M

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In a double-blind, placebo-controlled crossover trial 23 autistic children were treated with a single 40-mg dose of the opiate antagonist naltrexone. Drug effects were monitored by detailed playroom observations, actometers, and parents' checklist ratings (Aberrant Behavior Checklist, social items and target behaviors), Naltrexone treatment failed to produce significant changes in social behavior, but it did reduce irritability and target scores on behavior checklists. The playroom data indicated that naltrexone significantly affected indices of activity and attention.

引用

页码：203 / 215

页数：13

共 61 条

[1] INITIATORY AND REACTIVE BEHAVIOR IN YOUNG-CHILDREN WITH A PERVASIVE DEVELOPMENTAL DISORDER - 2 INDEPENDENT COMPONENTS IN COMMUNICATIVE-BEHAVIOR FOR DISTINGUISHING SUBGROUPS [J].