GAMMA-RAY IRRADIATION, AUTOCLAVE AND ETHYLENE-OXIDE STERILIZATION TO THERMOSETTING POLYURETHANE - STERILIZATION TO POLYURETHANE

被引：26

作者：

HIRATA, N ^{[1
]}

MATSUMOTO, KI ^{[1
]}

INISHITA, T ^{[1
]}

TAKENAKA, Y ^{[1
]}

SUMA, Y ^{[1
]}

SHINTANI, H ^{[1
]}

机构：

[1] NATL INST HLTH SCI,DEPT MED DEVICES,SETAGAYA KU,TOKYO 158,JAPAN

来源：

RADIATION PHYSICS AND CHEMISTRY | 1995年 / 46卷 / 03期

关键词：

D O I：

10.1016/0969-806X(94)00134-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Thermosetting polyurethane (PU) is widely used in a large variety of medical devices. 4,4'-methylenedianiline (MDA) was produced from PU by sterilization and it was studied for the relationship between urethane components or polymer characteristics and formation of MDA upon sterilization, using the commercially available dialyzers fabricated with different combination of isocyanate and polyol. We confirmed that the molecular-weight of polyol influenced the production of MDA upon sterilization.

引用

页码：377 / 381

页数：5

共 8 条

[1] IDENTIFICATION AND ANALYSIS OF POLYURETHANE RUBBERS BY INFRARED SPECTROSCOPY [J].

CORISH, PJ .

ANALYTICAL CHEMISTRY, 1959, 31 (08) :1298-1306

[2] CORRELATION OF HEPATOCELLULAR PROLIFERATION WITH HEPATOCARCINOGENICITY INDUCED BY THE MUTAGENIC NONCARCINOGEN - CARCINOGEN PAIR - 2,6-DIAMINOTOLUENE AND 2,4-DIAMINOTOLUENE [J].

CUNNINGHAM, ML ;

FOLEY, J ;

MARONPOT, RR ;

MATTHEWS, HB .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1991, 107 (03) :562-567

[3] POLYMERS FOR MEDICAL APPLICATIONS [J].

FROMMELT, H .

MAKROMOLEKULARE CHEMIE-MACROMOLECULAR SYMPOSIA, 1987, 12 :281-301

[4] DEGRADATION OF POLYURETHANES IN BIOMEDICAL APPLICATIONS - A REVIEW [J].

GRIESSER, HJ .

POLYMER DEGRADATION AND STABILITY, 1991, 33 (03) :329-354

[5] ANALYSIS OF A CARCINOGEN, 4,4'-METHYLENEDIANILINE, FROM THERMOSETTING POLYURETHANE DURING STERILIZATION [J].

SHINTANI, H ;

NAKAMURA, A .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (06) :354-357

[6] ANALYSIS OF THE CARCINOGEN 4,4'-METHYLENEDIANILINE (MDA) IN GAMMA-RAY AND IN AUTOCLAVE-STERILIZED POLYURETHANE [J].

SHINTANI, H ;

NAKAMURA, A .

FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1989, 333 (06) :637-640

[7] FORMATION OF 4,4'-METHYLENEDIANILINE IN POLYURETHANE POTTING MATERIALS BY EITHER GAMMA-RAY OR AUTOCLAVE STERILIZATION [J].

SHINTANI, H ;

NAKAMURA, A .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1991, 25 (10) :1275-1286

[8]

Shintani H, 1992, J RAD STERIL, V1, P11

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